This site needs JavaScript to work properly. Kidney Int 73: 994-1007. PUMA-α has an important role in cisplatin-induced tubular cell apoptosis . The aim of our study was to evaluate the incidence of chemotherapy toxicity induced by cisplatin and to analyze the influence of risk factors in the Tunisian population. Cisplatin in cancer therapy : Molecular Mechanisms of Action; 2015. p. 364–78. Found inside – Page 117Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney International, 73(9), 994–1007. PubMed PMID: 18272962. Rougier, F., Ducher, M., Maurin, M., et al. (2003). Aminoglycoside dosages and nephrotoxicity: ... Cisplatin is a widely used anti-neoplastic agent; however, its major limitation is the development of dose-dependent nephrotoxicity whose precise mechanisms are poorly understood. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. MeSH 1.2. Found inside – Page 1094Camussi G, Deregibus MC, Bruno S, Cantaluppi V, Biancone L. Exosomes/microvesicles as a mechanism of cell-to-cell communication. ... Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. 2016;2016:4320374. doi: 10.1155/2016/4320374. Introduction. cisplatin is a chemotherapeutic used in the treatment of many solid cancers, including head/neck cancer, lung cancer, and germline cancers (3, 11, 36).Although it is a potent choice for first-line treatment, cisplatin has several adverse side effects of which nephrotoxicity is its dose-limiting toxicity (3, 36). Nephrotoxicity is the primary dose-limiting toxicity, and various hydration regimens and supplementation strategies are used to prevent cisplatin … Morin inhibited the activation of CYP2E1, p65, P38, Bax, p53 and cleaved caspase 3. … View Article Google Scholar 5. This book presents a comprehensive and instructive management plan for physicians who care for CKD patients. ... Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Morin attenuated cisplatin-induced oxidative stress, inflammation and apoptosis. Epub 2014 May 24. Copyright © 2021 Elsevier B.V. or its licensors or contributors. eCollection 2021. Cisplatin is one of the most widely used and most potent chemotherapy drugs. CAS PubMed Article Google Scholar Recent research has shed significant new lights on the mechanism of cisplatin nephrotoxicity, especially on the signaling pathways leading to tubular cell death and inflammation. The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. It also includes presentations of novel animal experimental models using Cdo1 and CSAD knock-out mice. This volume provides the reader with an overview of taurine and its derivatives in modulating brain health. Found inside – Page 135Pabla N, Dong Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney Int. 2008;73(9):994–1007. Safirstein R, Winston J, Moel D, Dikman S, Guttenplan J. Cisplatin nephrotoxicity: Insights into mechanism. Acacia hydaspica R. Parker ethyl-acetate extract abrogates cisplatin-induced nephrotoxicity by targeting ROS and inflammatory cytokines. Careers. However, the exact mechanisms underlying nephrotoxicity is still unclear as there are many chicken-and-egg situations that need further clarification. 2008; 73(9): 994-1007. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. CISPLATIN NEPHROTOXICITY Nephrotoxicity was reported in the initial clinical trials of cisplatin chemotherapy.17 Now, it is recognized that the prevalence of cisplatin nephrotoxicity is high, occurring in However, little is known whether vit C has similar actions and enhances the anticancer effect of CP in tumor-bearing mice. The important mechanisms of cisplatin-induced nephrotoxicity are oxidative stress and p53 tumour suppressor protein activation . The adverse effect profile of cisplatin is well documented, but the prevention strategies to alleviate renal impairment due to treatment are less understood. Found inside – Page 162Pabla, N.; Dong, Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney Int. 2008, 73, 994–1007. [CrossRef] [PubMed] 10. Dugbartey, G.J.; Peppone, L.J.; de Graaf, I.A. An integrative view of cisplatin-induced ... Found inside – Page 35... xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors. Mol Cancer Ther 2008;7:3212–22. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 2008;73:994–1007. Disclaimer, National Library of Medicine Found inside – Page 166Drug Discov. Today, 2009, 14, 1075-1076. Hanigan, M.H.; Devarajan, P. Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther., 2003, 1, 47-61. Pabla, N.; Dong, Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int … ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Renoprotective mechanisms of morin in cisplatin-induced kidney injury. 8600 Rockville Pike We use cookies to help provide and enhance our service and tailor content and ads. A Randomized Trial Comparing the Nephrotoxicity of Cisplatin/Ifosfamide-Based Combination Chemotherapy with or without Amifostine in Patients with Solid Tumors. This study provides insights into the mechanisms underlying cisplatin-induced oto- and nephrotoxicity and compelling preclinical evidence for the potential utility of dopamine and L-mimosine in the safer administration of cisplatin. Morin inhibited the cisplatin-induced TNF-α and IL-1β production. Found inside – Page 119Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int. 73: 994—1007. SastryI and Kellie SI. 2005. Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine. Found inside – Page 37Pabla, N.; Dong, Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney Int. 2008, 73, 994–1007. [CrossRef] 11. Manohar, S.; Leung, N. Cisplatin nephrotoxicity: A review of the literature. J. Nephrol. Here we show that mitochondrial dysfunction is not only a feature of cisplatin nephrotoxicity, but that targeted delivery of superoxide dismutase mimetics to mitochondria largely prevents the renal effects of cisplatin. We focus on the docetaxel, cisplatin, and 5-fluorouracil regimen, which is called the TPF regimen, where the standard dose of cisplatin is 60 mg/m2. In addition to the association … Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Treatment with the matrix metalloprotease inhibitor GM-6001, a TNF-α antagonist, reduced urea levels in GM-6001 mice compared to cisplatin, showing treatment with GM-6001 enhanced renal function. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). Clipboard, Search History, and several other advanced features are temporarily unavailable. Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity Oxid Med Cell Longev. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. It has also been reported that oxidative stress may link to cisplatin-induced p53 activation . Standardized extract from the leaves of the Ginkgo biloba trees, labeled EGb761 (EGb), has been available on the market for its beneficial effects. Gene Delivery into Mammalian Cells: An Overview on Existing Approaches Employed In Vitro and In Vivo, by Peter Hahn and Elizabeth Scanlan * Strategies for the Preparation of Synthetic Transfection Vectors, by Asier Unciti-Broceta, Matthew N ... FOIA 2014 Jun;88(6):1249-56. doi: 10.1007/s00204-014-1239-1. Pabla, N. & Dong, Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Found inside – Page 484Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney International, 73, 994–1007. Pan, H., Chen, J., Shen, K., et al. (2015). Mitochondrial modulation by Epigallocatechin 3-Gallate ameliorates cisplatin induced ... Hsing CH, Tsai CC, Chen CL, Lin YH, Tseng PC, Satria RD, Lin CF. ... Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury. This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. Cisplatin was found to decrease the expression of the TauT through the activation of p in proximal tubular renal cells [ ]. 2015 Feb;67(2):133-41. doi: 10.1016/j.etp.2014.11.001. Published by Elsevier Inc. All rights reserved. Found insideIn this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. Found inside – Page 30Dalton Trans., 10670–10680, 2009; (b) Pabla, N. and Dong, Z., Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney Int., 73,994–1007, 2008. Goodsell, D.S., The Molecular Perspective: Cisplatin. 2008;73:994–1007. However, on a large scale, such as in chemotherapy, this defense mechanism may fail, resulting in nephrotoxicity. Pabla N, Dong G, Jiang M, Huang S, Kumar MV, Messing RO, Dong Z. J Clin Invest. Nephrotoxicity is characterized and scored by many parameters such as vacuolization, dilatation, hyaline cast, debris or degeneration in injured renal tissue. Cisplatin-Induced AKI in the Clinical Setting. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Found insideNew insightsinto the mechanism ofaminoglycoside nephrotoxicity: an integrative point of view. KidneyInt. 2011; 79(1):33–45. 31. ... Pabla, Dong, Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Commun Biol. 2011 Jul;121(7):2709-22. doi: 10.1172/JCI45586. Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. In Vitro Nephrotoxicity Studies of Established and Experimental Platinum-Based Compounds. Domitrović R, Cvijanović O, Pugel EP, Zagorac GB, Mahmutefendić H, Å koda M. Toxicology. A known complication of cisplatin administration is acute kidney injury (AKI). The major pathological feature of AKI is sublethal even lethal damage of the renal tubular epithelial cells (Yang et al., 2010). Cisplatin (CDDP) is a potent antitumor compound widely used with a notably side effect of nephrotoxicity inducing oxidative stress and apoptosis in kidneys. This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Please enable it to take advantage of the complete set of features! Exp Toxicol Pathol. A proper understanding of additional mechanisms contributing to cisplatin nephrotoxicity in Oct1/2 −/− mice is of fundamental relevance to the discovery and development of translational strategies that are completely renoprotective and … The purpose of this study was to investigate the ability of EGb to prevent the … Copyright © 2015 Elsevier B.V. All rights reserved. Kidney Int. Nephrotoxicity Nephrotoxicity results from a rapid decline of excretory mechanisms within the Copyright © 2021 Elsevier B.V. or its licensors or contributors. Would you like email updates of new search results? 2013 Aug 9;310:115-23. doi: 10.1016/j.tox.2013.05.015. Afsar T, Razak S, Aldisi D, Shabbir M, Almajwal A, Al Kheraif AA, Arshad M. Sci Rep. 2021 Aug 26;11(1):17248. doi: 10.1038/s41598-021-96509-y. e ective strategy to enhance the antitumor e cacy and to prevent cisplatin-induced nephrotoxicity [ ]. Kidney Int. Pabla N, Dong Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Ojha S, Venkataraman B, Kurdi A, Mahgoub E, Sadek B, Rajesh M. Oxid Med Cell Longev. Recently, some studies have focused on the associations between genetic alterations in the genes coding for … Cisplatin is an effective anti-cancer drug for the treatment of many solid tumors in humans. Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. While the toxicities of cisplatin include emesis, loss of appetite, ototoxicity and peripheral neuropathy, the main dose-limiting side effect of cisplatin is nephrotoxicity. Found inside – Page 125Antioxid Redox Signal 9:879–889 Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73:994–1007 Recknagel RO, Glende EA Jr, Dolak JK et al (1989) Mechanisms of carbon tetrachloride ... Vitamin C (vit C) has been shown to diminish cisplatin (CP)-induced nephrotoxicity and oxidative damage in healthy rats and mice. However, side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the use of cisplatin and related platinum-based therapeutics. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Found inside – Page 204Pabla N, Dong Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney Int 2008; 73:994–1007. 8. Rybak LP, Whitworth CA, Mukherjea D, et al. Mechanisms of cisplatininduced ototoxicity and prevention. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies.